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No pharmacokinetic studies of metformin have been conducted in patients with hepatic insufficiency see precautions .

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Our objective was to conduct a systematic review and meta-analysis of randomised and non-randomised studies to investigate the effect of metformin use compared with non-use on recurrence-free survival rfs , overall survival os and cancer-specific survival css in adults who have potentially curable solid tumours.

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Dapagliflozin; metformin moderate sulfonamides may enhance the hypoglycemic action of antidiabetic agents.

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In addition, an active glipizide controlled study of 52-weeks duration was conducted in 1172 patients with type 2 diabetes who had inadequate glycemic control on metformin.

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